Rhinovirus-Specific B-Cells Display Signature and Functionality Consistent With Age-Associated B-Cells

Age-Associated B Cells: A T-bet

Natural-Killer-like B Cells Display the Phenotypic and Functional Characteristics of Conventional B Cells.

Yann M. Kerdiles,1,8,* Francisca F. Almeida,2,3,8 Thornton Thompson,4,8 Michael Chopin,2,3,8 Margaux Vienne,1 Pierre Bruhns,5,6 Nicholas D. Huntington,2,3 David H. Raulet,4,9 Stephen L. Nutt,2,3,9 Gabrielle T. Belz,2,3,9 and Eric Vivier1,7,9 1Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France 2Walter and Eliza Hall Institute of Medical Research, ...

CD26+ Cord Blood Mononuclear Cells Significantly Produce B, T, and NK Cells

Background: Umbilical cord blood (UCB) is an alternative source of hematopoietic stem cell transplantation (HSCT), used in Leukemia treatment. CD26+ cells, a fraction of CD34 positive cells, are a major population of UCB cells which negatively regulate the in vivo homing and engraftment of HSCs. CD26 is highly expressed in various cells such as HSCs, immune cells, fibroblasts, and epithelial ce...

Clostridium butyricum in combination with specific immunotherapy converts antigen-specific B cells to regulatory B cells in asthmatic patients.

The effect of antigen specific immunotherapy (SIT) on asthma is supposed to be improved. Published data indicate that administration of probiotics alleviates allergic diseases. B cells play important roles in the pathogenesis of allergic diseases. This study aims to modulate antigen specific B cell property by the administration of Clostridium butyrate (CB) in combination with SIT. The results ...

Peripheral B cells latently infected with Epstein-Barr virus display molecular hallmarks of classical antigen-selected memory B cells.

Epstein-Barr virus (EBV) establishes a lifelong persistent infection within peripheral blood B cells with the surface phenotype of memory cells. To date there is no proof that these cells have the genotype of true germinal-center-derived memory B cells. It is critical to understand the relative contribution of viral mimicry versus antigen signaling to the production of these cells because EBV e...